Global conformational rearrangements during the activation of the GDP/GTP exchange factor Vav3
نویسندگان
چکیده
منابع مشابه
Global conformational rearrangements during the activation of the GDP/GTP exchange factor Vav3.
Activation of Rho/Rac GTPases during cell signaling requires the participation of GDP/GTP exchange factors of the Dbl family. Although the structure of the catalytic core of Dbl proteins has been established recently, the molecular changes that the full-length proteins experience during normal or oncogenic conditions of stimulation are still unknown. Here, we have used single-particle electron ...
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ژورنال
عنوان ژورنال: The EMBO Journal
سال: 2005
ISSN: 0261-4189,1460-2075
DOI: 10.1038/sj.emboj.7600617